4CFE

Structure of full length human AMPK in complex with a small molecule activator, a benzimidazole derivative (991)

4CFE の概要

• エントリーDOI: 10.2210/pdb4cfe/pdb
• 分子名称: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ... (7 entities in total)
• 機能のキーワード: transferase, nucleotide-binding, staurosporine-binding, serine/threonine-protein kinase, activator, carbohydrate binding module (cbm)
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 273331.57

構造登録者

Xiao, B.,Sanders, M.J.,Carmena, D.,Bright, N.J.,Haire, L.F.,Underwood, E.,Patel, B.R.,Heath, R.B.,Walker, P.A.,Hallen, S.,Giordanetto, F.,Martin, S.R.,Carling, D.,Gamblin, S.J. (登録日: 2013-11-14, 公開日: 2013-12-25, 最終更新日: 2023-12-20)

• 主引用文献: Xiao, B.,Sanders, M.J.,Carmena, D.,Bright, N.J.,Haire, L.F.,Underwood, E.,Patel, B.R.,Heath, R.B.,Walker, P.A.,Hallen, S.,Giordanetto, F.,Martin, S.R.,Carling, D.,Gamblin, S.J.; Structural Basis of Ampk Regulation by Small Molecule Activators.; Nat.Commun., 4:3017-, 2013; PubMed: 24352254; DOI: 10.1038/NCOMMS4017

実験手法