4CF6

Crystal structure of the complex of the P187S variant of human NAD(P) H:quinone oxidoreductase with Cibacron blue at 2.7 A resolution

Summary for 4CF6

• Entry DOI: 10.2210/pdb4cf6/pdb
• Related: 4CET
• Descriptor: NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, CIBACRON BLUE, ... (4 entities in total)
• Functional Keywords: flavoprotein, oxidoreductase, oxidoreductase-inhibitor complex, single amino acid exchange
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P15559
• Total number of polymer chains: 2
• Total formula weight: 69257.28

Authors

Lienhart, W.D.,Gudipati, V.,Uhl, M.K.,Binter, A.,Pulido, S.,Saf, R.,Zangger, K.,Gruber, K.,Macheroux, P. (deposition date: 2013-11-13, release date: 2014-08-27, Last modification date: 2023-12-20)

• Primary citation: Lienhart, W.D.,Gudipati, V.,Uhl, M.K.,Binter, A.,Pulido, S.,Saf, R.,Zangger, K.,Gruber, K.,Macheroux, P.; Collapse of the Native Structure by a Single Amino Acid Exchange in Human Nad(P)H:Quinone Oxidoreductase (Nqo1).; FEBS J., 281:4691-, 2014; PubMed: 25143260; DOI: 10.1111/FEBS.12975

Experimental method

X-RAY DIFFRACTION (2.694 Å)