4CDR
Human O-GlcNAc transferase in complex with a bisubstrate inhibitor, Goblin1
Summary for 4CDR
Entry DOI | 10.2210/pdb4cdr/pdb |
Related PRD ID | PRD_002043 |
Descriptor | UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT, GOBLIN1, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, inverting gt-b enzyme, bi-substrate analog inhibitor, transferase/transferase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Isoform 2: Mitochondrion. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: O15294 |
Total number of polymer chains | 8 |
Total formula weight | 331516.14 |
Authors | Schimpl, M.,Gundogdu, M.,van Aalten, D.M.F. (deposition date: 2013-11-05, release date: 2013-12-04, Last modification date: 2023-12-20) |
Primary citation | Borodkin, V.S.,Schimpl, M.,Gundogdu, M.,Rafie, K.,Dorfmueller, H.C.,Robinson, D.A.,Van Aalten, D.M. Bisubstrate Udp-Peptide Conjugates as Human O-Glcnac Transferase Inhibitors. Biochem.J., 457:497-, 2014 Cited by PubMed: 24256146DOI: 10.1042/BJ20131272 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
Download full validation report