4CCR
Crystal structure of the thioredoxin reductase apoenzyme from Entamoeba histolytica in the absence of the NADP cofactor
Summary for 4CCR
Entry DOI | 10.2210/pdb4ccr/pdb |
Related | 4CCQ |
Descriptor | THIOREDOXIN REDUCTASE, GOLD ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, amoebiasis, redox metabolism, oxidative stress, auranofin |
Biological source | ENTAMOEBA HISTOLYTICA |
Total number of polymer chains | 4 |
Total formula weight | 139048.46 |
Authors | Parsonage, D.,Kells, P.M.,Hirata, K.,Debnath, A.,Poole, L.B.,McKerrow, J.H.,Reed, S.L.,Podust, L.M. (deposition date: 2013-10-25, release date: 2014-11-05, Last modification date: 2023-12-20) |
Primary citation | Parsonage, D.,Sheng, F.,Hirata, K.,Debnath, A.,Mckerrow, J.H.,Reed, S.L.,Abagyan, R.,Poole, L.B.,Podust, L.M. X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action. J.Struct.Biol., 194:180-, 2016 Cited by PubMed: 26876147DOI: 10.1016/J.JSB.2016.02.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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