4CCR
Crystal structure of the thioredoxin reductase apoenzyme from Entamoeba histolytica in the absence of the NADP cofactor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0045454 | biological_process | cell redox homeostasis |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019430 | biological_process | removal of superoxide radicals |
| C | 0045454 | biological_process | cell redox homeostasis |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019430 | biological_process | removal of superoxide radicals |
| D | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU A 1315 |
| Chain | Residue |
| A | CYS286 |
| A | HOH2083 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE AU B 1315 |
| Chain | Residue |
| B | CYS286 |
| B | HOH2067 |
| B | HOH2075 |
| B | HOH2080 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU C 1315 |
| Chain | Residue |
| C | CYS286 |
| C | HOH2037 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE AU D 1315 |
| Chain | Residue |
| D | HOH2019 |
| D | CYS286 |
| site_id | AC5 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD D 1316 |
| Chain | Residue |
| B | TYR22 |
| B | HOH2007 |
| B | HOH2010 |
| D | GLY11 |
| D | SER12 |
| D | GLY13 |
| D | PRO14 |
| D | ALA15 |
| D | TYR33 |
| D | GLU34 |
| D | GLY35 |
| D | ALA38 |
| D | VAL41 |
| D | ALA42 |
| D | GLY45 |
| D | GLN46 |
| D | LEU47 |
| D | THR50 |
| D | ASN55 |
| D | THR87 |
| D | ILE88 |
| D | THR117 |
| D | GLY118 |
| D | ALA119 |
| D | GLY283 |
| D | ASP284 |
| D | ARG291 |
| D | GLN292 |
| D | ALA293 |
| D | ALA296 |
| D | HOH2014 |
| D | HOH2015 |
| D | HOH2022 |
| site_id | AC6 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD B 1316 |
| Chain | Residue |
| B | ILE10 |
| B | GLY11 |
| B | SER12 |
| B | GLY13 |
| B | PRO14 |
| B | ALA15 |
| B | TYR33 |
| B | GLU34 |
| B | GLY35 |
| B | ALA38 |
| B | VAL41 |
| B | ALA42 |
| B | GLY45 |
| B | GLN46 |
| B | LEU47 |
| B | THR50 |
| B | ASN55 |
| B | ILE88 |
| B | ALA116 |
| B | THR117 |
| B | GLY118 |
| B | ALA119 |
| B | TRP133 |
| B | CYS143 |
| B | GLY283 |
| B | ASP284 |
| B | ARG291 |
| B | GLN292 |
| B | ALA293 |
| B | ALA296 |
| B | HOH2005 |
| B | HOH2013 |
| B | HOH2017 |
| B | HOH2019 |
| B | HOH2021 |
| B | HOH2046 |
| D | TYR22 |
| site_id | AC7 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD A 1316 |
| Chain | Residue |
| A | THR117 |
| A | GLY118 |
| A | TRP133 |
| A | CYS143 |
| A | GLY283 |
| A | ASP284 |
| A | ARG291 |
| A | GLN292 |
| A | ALA293 |
| A | HOH2008 |
| A | HOH2016 |
| A | HOH2022 |
| A | HOH2024 |
| A | HOH2026 |
| A | HOH2027 |
| A | HOH2051 |
| C | TYR22 |
| A | ILE10 |
| A | GLY11 |
| A | SER12 |
| A | GLY13 |
| A | PRO14 |
| A | ALA15 |
| A | TYR33 |
| A | GLU34 |
| A | GLY35 |
| A | ALA38 |
| A | VAL41 |
| A | ALA42 |
| A | GLY45 |
| A | GLN46 |
| A | LEU47 |
| A | ILE53 |
| A | ASN55 |
| A | THR87 |
| A | ILE88 |
| site_id | AC8 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD C 1316 |
| Chain | Residue |
| A | TYR22 |
| A | HOH2009 |
| C | ILE10 |
| C | GLY11 |
| C | SER12 |
| C | GLY13 |
| C | PRO14 |
| C | ALA15 |
| C | TYR33 |
| C | GLU34 |
| C | GLY35 |
| C | ALA38 |
| C | VAL41 |
| C | ALA42 |
| C | GLY45 |
| C | GLN46 |
| C | LEU47 |
| C | ASN55 |
| C | ILE88 |
| C | THR117 |
| C | GLY118 |
| C | TRP133 |
| C | CYS143 |
| C | GLY283 |
| C | ASP284 |
| C | ARG291 |
| C | GLN292 |
| C | ALA293 |
| C | ALA296 |
| C | HOH2001 |
| C | HOH2005 |
| C | HOH2007 |
| C | HOH2016 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 23 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CaiCDGavpiFrnkvLmVVGGGD |
| Chain | Residue | Details |
| A | CYS140-ASP162 |
