4CCR

Crystal structure of the thioredoxin reductase apoenzyme from Entamoeba histolytica in the absence of the NADP cofactor

Summary for 4CCR

Entry DOI	10.2210/pdb4ccr/pdb
Related	4CCQ
Descriptor	THIOREDOXIN REDUCTASE, GOLD ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywords	oxidoreductase, amoebiasis, redox metabolism, oxidative stress, auranofin
Biological source	ENTAMOEBA HISTOLYTICA
Total number of polymer chains	4
Total formula weight	139048.46
Authors	Parsonage, D.,Kells, P.M.,Hirata, K.,Debnath, A.,Poole, L.B.,McKerrow, J.H.,Reed, S.L.,Podust, L.M. (deposition date: 2013-10-25, release date: 2014-11-05, Last modification date: 2023-12-20)
Primary citation	Parsonage, D.,Sheng, F.,Hirata, K.,Debnath, A.,Mckerrow, J.H.,Reed, S.L.,Abagyan, R.,Poole, L.B.,Podust, L.M. X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action. J.Struct.Biol., 194:180-, 2016 Cited by PubMed: 26876147 DOI: 10.1016/J.JSB.2016.02.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation