4CCQ

Crystal structure of the thioredoxin reductase from Entamoeba histolytica with NADP

4CCQ の概要

• エントリーDOI: 10.2210/pdb4ccq/pdb
• 関連するPDBエントリー: 4CCR
• 分子名称: THIOREDOXIN REDUCTASE, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, amoebiasis, redox metabolism, oxidative stress, auranofin
• 由来する生物種: ENTAMOEBA HISTOLYTICA
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70862.35

構造登録者

Parsonage, D.,Kells, P.M.,Hirata, K.,Debnath, A.,Poole, L.B.,McKerrow, J.H.,Reed, S.L.,Podust, L.M. (登録日: 2013-10-24, 公開日: 2014-11-05, 最終更新日: 2023-12-20)

• 主引用文献: Parsonage, D.,Sheng, F.,Hirata, K.,Debnath, A.,Mckerrow, J.H.,Reed, S.L.,Abagyan, R.,Poole, L.B.,Podust, L.M.; X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action.; J.Struct.Biol., 194:180-, 2016; PubMed: 26876147; DOI: 10.1016/J.JSB.2016.02.015

実験手法

X-RAY DIFFRACTION (1.5 Å)