4CB5
Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)
Summary for 4CB5
Entry DOI | 10.2210/pdb4cb5/pdb |
Related | 4CB4 |
Descriptor | POLYMERASE BASIC SUBUNIT 2, 9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | transferase, cap-binding inhibitors |
Biological source | Influenza A virus (A/duck/Shantou/4610/2003(H5N1)) |
Cellular location | Host nucleus : Q2LG68 |
Total number of polymer chains | 1 |
Total formula weight | 19337.63 |
Authors | Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. (deposition date: 2013-10-10, release date: 2013-10-30, Last modification date: 2023-12-20) |
Primary citation | Pautus, S.,Sehr, P.,Lewis, J.,Fortune, A.,Wolkerstorfer, A.,Szolar, O.,Gulligay, D.,Lunardi, T.,Decout, J.L.,Cusack, S. New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain J.Med.Chem., 56:8915-, 2013 Cited by PubMed: 24134208DOI: 10.1021/JM401369Y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report