4CAW

Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand

Summary for 4CAW

• Entry DOI: 10.2210/pdb4caw/pdb
• Related: 4CAV 4CAX
• Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, TETRADECANOYL-COA, ... (4 entities in total)
• Functional Keywords: transferase, drug discovery
• Biological source: ASPERGILLUS FUMIGATUS
• Cellular location: Cytoplasm: Q9UVX3
• Total number of polymer chains: 1
• Total formula weight: 48958.64

Authors

Robinson, D.A.,Fang, W.,Raimi, O.G.,Blair, D.E.,Harrison, J.,Ruda, G.F.,Lockhart, D.E.A.,Torrie, L.S.,Wyatt, P.G.,Gilbert, I.H.,Van Aalten, D.M.F. (deposition date: 2013-10-09, release date: 2014-09-17, Last modification date: 2016-03-23)

• Primary citation: Fang, W.,Robinson, D.A.,Raimi, O.G.,Blair, D.E.,Harrison, J.R.,Lockhart, D.E.A.,Torrie, L.S.,Ruda, G.F.,Wyatt, P.G.,Gilbert, I.H.,Van Aalten, D.M.F.; N-Myristoyltransferase is a Cell Wall Target in Aspergillus Fumigatus.; Acs Chem.Biol., 10:1425-, 2015; PubMed: 25706802; DOI: 10.1021/CB5008647

Experimental method

X-RAY DIFFRACTION (2.5 Å)