4CAW
Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a pyrazole sulphonamide ligand
Summary for 4CAW
Entry DOI | 10.2210/pdb4caw/pdb |
Related | 4CAV 4CAX |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, 2,6-DICHLORO-4-(2-PIPERAZIN-1-YLPYRIDIN-4-YL)-N-(1,5-DIMETHYL,3-ISOBUTYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, TETRADECANOYL-COA, ... (4 entities in total) |
Functional Keywords | transferase, drug discovery |
Biological source | ASPERGILLUS FUMIGATUS |
Cellular location | Cytoplasm: Q9UVX3 |
Total number of polymer chains | 1 |
Total formula weight | 48958.64 |
Authors | Robinson, D.A.,Fang, W.,Raimi, O.G.,Blair, D.E.,Harrison, J.,Ruda, G.F.,Lockhart, D.E.A.,Torrie, L.S.,Wyatt, P.G.,Gilbert, I.H.,Van Aalten, D.M.F. (deposition date: 2013-10-09, release date: 2014-09-17, Last modification date: 2024-05-08) |
Primary citation | Fang, W.,Robinson, D.A.,Raimi, O.G.,Blair, D.E.,Harrison, J.R.,Lockhart, D.E.A.,Torrie, L.S.,Ruda, G.F.,Wyatt, P.G.,Gilbert, I.H.,Van Aalten, D.M.F. N-Myristoyltransferase is a Cell Wall Target in Aspergillus Fumigatus. Acs Chem.Biol., 10:1425-, 2015 Cited by PubMed: 25706802DOI: 10.1021/CB5008647 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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