4CAP
Structure of rat neuronal nitric oxide synthase heme domain in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2- amine
Summary for 4CAP
Entry DOI | 10.2210/pdb4cap/pdb |
Related | 4CAM 4CAN 4CAO 4CAQ 4CAR 4CDT 4CFT |
Descriptor | NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | oxidoreductase, nitric oxide synthase, inhibitor complex |
Biological source | RATTUS NORVEGICUS (NORWAY RAT) |
Cellular location | Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100142.78 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2013-10-08, release date: 2014-02-19, Last modification date: 2024-05-08) |
Primary citation | Cinelli, M.A.,Li, H.,Chreifi, G.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Simplified 2-Aminoquinoline-Based Scaffold for Potent and Selective Neuronal Nitric Oxide Synthase Inhibition. J.Med.Chem., 57:1513-, 2014 Cited by PubMed: 24472039DOI: 10.1021/JM401838X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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