4CAE
Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 20b)
Summary for 4CAE
Entry DOI | 10.2210/pdb4cae/pdb |
Related | 4CAF |
Descriptor | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, CHLORIDE ION, ... (8 entities in total) |
Functional Keywords | transferase, myristoylation, malaria, inhibitor, benzothiophene |
Biological source | PLASMODIUM VIVAX (MALARIA PARASITE P. VIVAX) |
Total number of polymer chains | 3 |
Total formula weight | 139624.68 |
Authors | Rackham, M.D.,Brannigan, J.A.,Rangachari, K.,Wilkinson, A.J.,Holder, A.A.,Tate, E.W.,Leatherbarrow, R.J. (deposition date: 2013-10-08, release date: 2014-04-02, Last modification date: 2024-05-08) |
Primary citation | Rackham, M.D.,Brannigan, J.A.,Rangachari, K.,Meister, S.,Wilkinson, A.J.,Holder, A.A.,Leatherbarrow, R.J.,Tate, E.W. Design and Synthesis of High Affinity Inhibitors of Plasmodium Falciparum and Plasmodium Vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (Lelp). J.Med.Chem., 57:2773-, 2014 Cited by PubMed: 24641010DOI: 10.1021/JM500066B PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.46 Å) |
Structure validation
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