4C7T
Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor
Summary for 4C7T
| Entry DOI | 10.2210/pdb4c7t/pdb |
| Descriptor | FOCAL ADHESION KINASE 1, N-methyl-2-[[4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl]amino]benzamide, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | transferase, kinase inhibitor, atp-binding, integrin signaling |
| Biological source | GALLUS GALLUS (CHICKEN) |
| Total number of polymer chains | 1 |
| Total formula weight | 32238.29 |
| Authors | Le Coq, J.,Lietha, D. (deposition date: 2013-09-25, release date: 2014-04-02, Last modification date: 2023-12-20) |
| Primary citation | Dao, P.,Jarray, R.,Smith, N.,Lepelletier, Y.,Le Coq, J.,Lietha, D.,Hadj-Slimane, R.,Herbeuval, J.P.,Garbay, C.,Raynaud, F.,Chen, H. Inhibition of Both Focal Adhesion Kinase and Fibroblast Growth Factor Receptor 2 Pathways Induces Anti-Tumor and Anti-Angiogenic Activities. Cancer Lett., 348:88-, 2014 Cited by PubMed: 24657306DOI: 10.1016/J.CANLET.2014.03.007 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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