4C78
Complex of human Sirt3 with Bromo-Resveratrol and ACS2 peptide
Summary for 4C78
Entry DOI | 10.2210/pdb4c78/pdb |
Related | 4C7B |
Descriptor | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, ACETYL-COENZYME A SYNTHETASE 2-LIKE, MITOCHONDRIAL, 5-[(E)-2-(4-bromophenyl)ethenyl]benzene-1,3-diol, ... (5 entities in total) |
Functional Keywords | hydrolase, sirtuin, inhibitor, activation, resveratrol, sirt1, metabolic sensor, metabolism, aging |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Mitochondrion matrix: Q9NTG7 Q9NUB1 |
Total number of polymer chains | 2 |
Total formula weight | 33089.29 |
Authors | Nguyen, G.T.T.,Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-09-19, release date: 2013-11-20, Last modification date: 2023-12-20) |
Primary citation | Nguyen, G.T.T.,Gertz, M.,Steegborn, C. Crystal Structures of Sirt3 Complexes with 4'-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism. Chem.Biol., 20:1375-, 2013 Cited by PubMed: 24211137DOI: 10.1016/J.CHEMBIOL.2013.09.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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