4C67
Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains
Summary for 4C67
Entry DOI | 10.2210/pdb4c67/pdb |
Related | 4C66 |
Descriptor | BROMODOMAIN-CONTAINING PROTEIN 4, 13-methyl-7-phenyl-3-thia-1,8,11,12-tetraazatricyclo trideca-2(6),4,7,10,12-pentaene, 1,2-ETHANEDIOL, ... (4 entities in total) |
Functional Keywords | cell cycle, histone, epigenetic reader brd4, bromodomain containing protein 4, antagonist |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15503.86 |
Authors | Chung, C.,Mirguet, O. (deposition date: 2013-09-17, release date: 2013-10-02, Last modification date: 2024-05-08) |
Primary citation | Mirguet, O.,Gosmini, R.,Toum, J.,Clement, C.,Barnathan, M.,Brusq, J.,Mordaunt, J.E.,Grimes, R.,Crowe, M.,Pineau, O.,Ajakane, M.,Daugan, A.,Jeffrey, P.,Cutler, L.,Haynes, A.,Smithers, N.,Chung, C.,Bamborough, P.,Uings, I.J.,Lewis, T.,Witherington, J.,Parr, N.,Prinjha, R.,Nicodeme, E. Discovery of Epigenetic Regulator I-Bet762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the Bet Bromodomains. J.Med.Chem., 56:7501-, 2013 Cited by PubMed: 24015967DOI: 10.1021/JM401088K PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
Download full validation report