4C61
Inhibitors of Jak2 Kinase domain
Summary for 4C61
Entry DOI | 10.2210/pdb4c61/pdb |
Related | 4C62 |
Descriptor | TYROSINE-PROTEIN KINASE JAK2, N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-7-methyl-N4-(1-methylimidazol-4-yl)thieno[3,2-d]pyrimidine-2,4-diamine, ACETATE ION, ... (4 entities in total) |
Functional Keywords | kinase, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Endomembrane system ; Peripheral membrane protein : O60674 |
Total number of polymer chains | 2 |
Total formula weight | 71137.63 |
Authors | Read, J.A.,Green, I.,Pollard, H.,Howard, T. (deposition date: 2013-09-17, release date: 2014-01-08, Last modification date: 2023-12-20) |
Primary citation | Su, Q.,Ioannidis, S.,Chuaqui, C.,Almeida, L.,Alimzhanov, M.,Bebernitz, G.,Bell, K.,Block, M.,Howard, T.,Huang, S.,Huszar, D.,Read, J.A.,Rivard Costa, C.,Shi, J.,Su, M.,Ye, M.,Zinda, M. Discovery of 1-Methyl-1H-Imidazole Derivatives as Potent Jak2 Inhibitors. J.Med.Chem., 57:144-, 2014 Cited by PubMed: 24359159DOI: 10.1021/JM401546N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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