4C59

Structure of GAK kinase in complex with nanobody (NbGAK_4)

Summary for 4C59

• Entry DOI: 10.2210/pdb4c59/pdb
• Related: 4C57 4C58
• Descriptor: Cyclin-G-associated kinase, NANOBODY, (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}, ... (4 entities in total)
• Functional Keywords: transferase, kinase, conformational plasticity, activation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 53634.44

Authors

Chaikuad, A.,Keates, T.,Allerston, C.K.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Muller-Knapp, S. (deposition date: 2013-09-10, release date: 2013-10-09, Last modification date: 2023-12-20)

• Primary citation: Chaikuad, A.,Keates, T.,Vincke, C.,Kaufholz, M.,Zenn, M.,Zimmermann, B.,Gutierrez, C.,Zhang, R.G.,Hatzos-Skintges, C.,Joachimiak, A.,Muyldermans, S.,Herberg, F.W.,Knapp, S.,Muller, S.; Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies.; Biochem. J., 459:59-69, 2014; PubMed: 24438162; DOI: 10.1042/BJ20131399

Experimental method

X-RAY DIFFRACTION (2.8 Å)