4C58

Structure of GAK kinase in complex with nanobody (NbGAK_4)

Summary for 4C58

Entry DOI	10.2210/pdb4c58/pdb
Related	4C57 4C59
Descriptor	Cyclin-G-associated kinase, nanobody, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	transferase, kinase, conformational plasticity, activation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	53783.59
Authors	Chaikuad, A.,Keates, T.,Allerston, C.K.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Muller-Knapp, S. (deposition date: 2013-09-10, release date: 2013-10-09, Last modification date: 2023-12-20)
Primary citation	Chaikuad, A.,Keates, T.,Vincke, C.,Kaufholz, M.,Zenn, M.,Zimmermann, B.,Gutierrez, C.,Zhang, R.G.,Hatzos-Skintges, C.,Joachimiak, A.,Muyldermans, S.,Herberg, F.W.,Knapp, S.,Muller, S. Structure of cyclin G-associated kinase (GAK) trapped in different conformations using nanobodies. Biochem. J., 459:59-69, 2014 Cited by PubMed: 24438162 DOI: 10.1042/BJ20131399 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.16 Å)

Structure validation