4C57

Structure of GAK kinase in complex with a nanobody

Summary for 4C57

Entry DOI	10.2210/pdb4c57/pdb
Related	4C58 4C59
Descriptor	Cyclin-G-associated kinase, NANOBODY, SULFATE ION, ... (6 entities in total)
Functional Keywords	transferase, kinase, conformational plasticity, activation
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	109002.92
Authors	Chaikuad, A.,Keates, T.,Krojer, T.,Allerston, C.K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Muller-Knapp, S. (deposition date: 2013-09-10, release date: 2013-10-09, Last modification date: 2023-12-20)
Primary citation	Chaikuad, A.,Keates, T.,Vincke, C.,Kaufholz, M.,Zenn, M.,Zimmermann, B.,Gutierrez, C.,Zhang, R.,Hatzos-Skintges, C.,Joachimiak, A.,Muyldermans, S.,Herberg, F.W.,Knapp, S.,Muller, S. Structure of Cyclin G-Associated Kinase (Gak) Trapped in Different Conformations Using Nanobodies. Biochem.J., 459:59-, 2014 Cited by PubMed: 24438162 DOI: 10.1042/BJ20131399 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation