4C52
Crystal structure of Bcl-xL in complex with benzoylurea compound (39b)
Summary for 4C52
Entry DOI | 10.2210/pdb4c52/pdb |
Related | 4C5D |
Descriptor | BCL-2-LIKE PROTEIN 1, (R)-2-(3-(3-((2,4-DIFLUOROPENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)-3-(ISOBUTYLTHIO) PROPANOIC ACID, SULFATE ION, ... (5 entities in total) |
Functional Keywords | apoptosis |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Isoform Bcl-X(L): Mitochondrion inner membrane : Q07817 |
Total number of polymer chains | 2 |
Total formula weight | 38258.32 |
Authors | Roy, M.J.,Brady, R.M.,Lessene, G.,Colman, P.M.,Czabotar, P.E. (deposition date: 2013-09-10, release date: 2014-02-05, Last modification date: 2023-12-20) |
Primary citation | Brady, R.M.,Vom, A.,Roy, M.J.,Toovey, N.,Smith, B.J.,Moss, R.M.,Hazis, E.,Huang, D.C.S.,Parisot, J.P.,Yang, H.,Street, I.P.,Colman, P.M.,Czabotar, P.E.,Baell, J.B.,Lessene, G. De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization. J.Med.Chem., 57:1323-, 2014 Cited by PubMed: 24456288DOI: 10.1021/JM401948B PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.049 Å) |
Structure validation
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