4C3R

Structure of dephosphorylated Aurora A (122-403) bound to AMPPCP

Summary for 4C3R

Entry DOI	10.2210/pdb4c3r/pdb
Related	4C3P
Descriptor	AURORA KINASE A, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER (2 entities in total)
Functional Keywords	transferase, aurora a, activation, cell cycle, cancer
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	33194.67
Authors	Zorba, A.,Kutter, S.,Cho, Y.-J.,Kern, D. (deposition date: 2013-08-26, release date: 2014-05-28, Last modification date: 2023-12-20)
Primary citation	Zorba, A.,Buosi, V.,Kutter, S.,Kern, N.,Pontiggia, F.,Cho, Y.J.,Kern, D. Molecular Mechanism of Aurora a Kinase Autophosphorylation and its Allosteric Activation by Tpx2. Elife, 3:02667-, 2014 Cited by PubMed: 24867643 DOI: 10.7554/ELIFE.02667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.79 Å)

Structure validation