4C3A

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3S, 5R)-5-(((6-amino-4-methylpyridin-2-yl)methoxy) methyl)pyrrolidin-3-yl)oxy) methyl)-4-methylpyridin-2-amine

Summary for 4C3A

Entry DOI	10.2210/pdb4c3a/pdb
Related	4C39
Descriptor	NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
Functional Keywords	oxidoreductase, inhibitor complex
Biological source	RATTUS NORVEGICUS (NORWAY RAT)
Cellular location	Cell membrane : P29473
Total number of polymer chains	2
Total formula weight	102370.17
Authors	Li, H.,Poulos, T.L. (deposition date: 2013-08-22, release date: 2014-04-02, Last modification date: 2017-03-29)
Primary citation	Jing, Q.,Li, H.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. An Accessible Chiral Linker to Enhance Potency and Selectivity of Neuronal Nitric Oxide Synthase Inhibitors. Acs Med.Chem.Lett., 5:56-, 2014 Cited by PubMed: 24660051 DOI: 10.1021/ML400381S PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation