4C2Z

Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and inhibitor bound

Summary for 4C2Z

• Entry DOI: 10.2210/pdb4c2z/pdb
• Related: 4C2X 4C2Y
• Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE 1, TETRADECANOYL-COA, 2,6-dichloro-4-(2-piperazin-1-ylpyridin-4-yl)-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzenesulfonamide, ... (8 entities in total)
• Functional Keywords: transferase, myristoylation
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cytoplasm: P30419
• Total number of polymer chains: 2
• Total formula weight: 99242.86

Authors

Thinon, E.,Serwa, R.A.,Brannigan, J.A.,Brassat, U.,Wright, M.H.,Heal, W.P.,Wilkinson, A.J.,Mann, D.J.,Tate, E.W. (deposition date: 2013-08-20, release date: 2014-10-01, Last modification date: 2024-05-08)

• Primary citation: Thinon, E.,Serwa, R.A.,Broncel, M.,Brannigan, J.A.,Brassat, U.,Wright, M.H.,Heal, W.P.,Wilkinson, A.J.,Mann, D.J.,Tate, E.W.; Chemical Proteomics Defines the Mammalian N- Myristoylated Proteome in Live Cells Global Profiling of Co- and Post-Translationally N-Myristoylated Proteomes in Human Cells.; Nat.Commun., 5:4919-, 2014; PubMed: 25255805; DOI: 10.1038/NCOMMS5919

Experimental method

X-RAY DIFFRACTION (2.08 Å)