4C2P

Crystal structure of human testis angiotensin-I converting enzyme mutant R522K in complex with captopril

Summary for 4C2P

• Entry DOI: 10.2210/pdb4c2p/pdb
• Related: 4C2N 4C2O 4C2Q 4C2R
• Descriptor: ANGIOTENSIN-CONVERTING ENZYME, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (8 entities in total)
• Functional Keywords: hydrolase, chloride activation, hypertension
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 69278.33

Authors

Masuyer, G.,Yates, C.J.,Schwager, S.L.U.,Mohd, A.,Sturrock, E.D.,Acharya, K.R. (deposition date: 2013-08-19, release date: 2013-12-11, Last modification date: 2023-12-20)

• Primary citation: Yates, C.J.,Masuyer, G.,Schwager, S.L.U.,Mohd, A.,Sturrock, E.D.,Acharya, K.R.; Molecular and Thermodynamic Mechanisms of the Chloride Dependent Human Angiotensin-I Converting Enzyme (Ace); J.Biol.Chem., 289:1798-, 2014; PubMed: 24297181; DOI: 10.1074/JBC.M113.512335

Experimental method

X-RAY DIFFRACTION (1.99 Å)