4BZT

The Solution Structure of the MLN 944-d(ATGCAT)2 Complex

Summary for 4BZT

• Entry DOI: 10.2210/pdb4bzt/pdb
• Related: 4BZU 4BZV
• Descriptor: DNA, 1-METHYL-9-[12-(9-METHYLPHENAZIN-10-IUM-1-YL)-12-OXO-2,11-DIAZA-5,8-DIAZONIADODEC-1-ANOYL]PHENAZIN-10-IUM (2 entities in total)
• Functional Keywords: bis(phenazine-1-carboxamides), dna, intercalation, drug design, anticancer drug.
• Biological source: SYNTHETIC CONSTRUCT
• Total number of polymer chains: 2
• Total formula weight: 4207.18

Authors

Serobian, A.,Thomas, D.S.,Ball, G.E.,Denny, W.A.,Wakelin, L.P.G. (deposition date: 2013-07-30, release date: 2013-08-21, Last modification date: 2014-09-03)

• Primary citation: Serobian, A.,Thomas, D.S.,Ball, G.E.,Denny, W.A.,Wakelin, L.P.G.; The Solution Structure of Bis(Phenazine-1-Carboxamide)-DNA Complexes: Mln 944 Binding Corrected and Extended.; Biopolymers, 101:1099-, 2014; PubMed: 24898663; DOI: 10.1002/BIP.22513

Experimental method

SOLUTION NMR