4BXN

Eg5(WT) complex

Summary for 4BXN

• Entry DOI: 10.2210/pdb4bxn/pdb
• Descriptor: KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CADMIUM ION, ... (6 entities in total)
• Functional Keywords: motor protein, mitosis
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 86756.35

Authors

Talapatra, S.K.,Anthony, N.G.,Mackay, S.P.,Kozielski, F. (deposition date: 2013-07-15, release date: 2013-07-31, Last modification date: 2024-02-07)

• Primary citation: Talapatra, S.K.,Anthony, N.G.,Mackay, S.P.,Kozielski, F.; The Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate Sb743921 by an Allosteric Resistance Mechanism.; J.Med.Chem., 56:6317-, 2013; PubMed: 23875972; DOI: 10.1021/JM4006274

Experimental method

X-RAY DIFFRACTION (2.793 Å)