4BXL

Structure of alpha-synuclein in complex with an engineered binding protein

Summary for 4BXL

Entry DOI	10.2210/pdb4bxl/pdb
Descriptor	AS69, ALPHA SYNUCLEIN (2 entities in total)
Functional Keywords	fibril, amyloid, parkinson's disease, protein aggregation, protein engineering, protein misfolding, scaffold proteins
Biological source	SYNTHETIC CONSTRUCT More
Cellular location	Cytoplasm: P37840
Total number of polymer chains	3
Total formula weight	12380.70
Authors	Mirecka, E.A.,Shaykhalishahi, H.,Lecher, J.,Stoldt, M.,Hoyer, W. (deposition date: 2013-07-12, release date: 2014-05-21)
Primary citation	Mirecka, E.A.,Shaykhalishahi, H.,Gauhar, A.,Akgul, S.,Lecher, J.,Willbold, D.,Stoldt, M.,Hoyer, W. Sequestration of a Beta-Hairpin for Control of Alpha-Synuclein Aggregation. Angew.Chem.Int.Ed.Engl., 53:4227-, 2014 Cited by PubMed: 24623599 DOI: 10.1002/ANIE.201309001 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation