4BW4
The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand
Summary for 4BW4
Entry DOI | 10.2210/pdb4bw4/pdb |
Related | 4BW1 4BW2 4BW3 |
Descriptor | BROMODOMAIN-CONTAINING PROTEIN 4, 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(2-(trifluoromethoxy)phenyl)-1h-imidazo[4,5-c][1,5]naphthyridin-2(3h)-one (3 entities in total) |
Functional Keywords | transcription, inhibitor, histone, epigenetic reader, antagonist |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Nucleus: O60885 |
Total number of polymer chains | 1 |
Total formula weight | 15570.77 |
Authors | Chung, C.,Mirguet, O.,Lamotte, Y.,Bamborough, P.,Delannee, D.,Bouillot, A.,Gellibert, F.,Krysa, G.,Lewis, A.,Witherington, J.,Huet, P.,Dudit, Y.,Trottet, L.,Nicodeme, E. (deposition date: 2013-06-29, release date: 2013-09-11, Last modification date: 2024-05-08) |
Primary citation | Mirguet, O.,Lamotte, Y.,Chung, C.,Bamborough, P.,Delannee, D.,Bouillot, A.,Gellibert, F.,Krysa, G.,Lewis, A.,Witherington, J.,Huet, P.,Dudit, Y.,Trottet, L.,Nicodeme, E. Naphthyridines as Novel Bet Family Bromodomain Inhibitors. Chemmedchem, 9:589-, 2014 Cited by PubMed: 24000170DOI: 10.1002/CMDC.201300259 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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