4BW4
The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BROMODOMAIN-CONTAINING PROTEIN 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | BRD4, PROTEIN HUNK1 |
| 2 | B (A) | 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(2-(trifluoromethoxy)phenyl)-1h-imidazo[4,5-c][1,5]naphthyridin-2(3h)-one | non-polymer | 471.4 | 1 | Chemie (9B6) | |||
| 3 | C (A) | water | water | 18.0 | 231 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15099.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 471.4 | |
| All* | Total formula weight | 15570.8 |
