4BTH

The LeuA146Trp,PheB24Tyr Double Mutant of the Quorum Quenching N-acyl Homoserine Lactone Acylase PvdQ Has an Altered Substrate Specificity Towards Small Acyl Chains

Summary for 4BTH

Entry DOI	10.2210/pdb4bth/pdb
Related	2WYB 2WYC 2WYD 2WYE
Descriptor	ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT ALPHA, ACYL-HOMOSERINE LACTONE ACYLASE PVDQ SUBUNIT BETA, GLYCEROL, ... (4 entities in total)
Functional Keywords	zymogen, hydrolase, quorum quenching
Biological source	PSEUDOMONAS AERUGINOSA More
Cellular location	Periplasm (Probable): Q9I194 Q9I194
Total number of polymer chains	2
Total formula weight	79632.36
Authors	Koch, G.,Nadal-Jimenez, P.,Reis, C.R.,Muntendam, R.,Bokhove, M.,Melillo, E.,Dijkstra, B.W.,Cool, R.H.,Quax, W.J. (deposition date: 2013-06-18, release date: 2014-01-22, Last modification date: 2023-12-20)
Primary citation	Koch, G.,Nadal-Jimenez, P.,Reis, C.R.,Muntendam, R.,Bokhove, M.,Melillo, E.,Dijkstra, B.W.,Cool, R.H.,Quax, W.J. Reducing Virulence of the Human Pathogen Burkholderia by Altering the Substrate Specificity of the Quorum-Quenching Acylase Pvdq Proc.Natl.Acad.Sci.USA, 111:1568-, 2014 Cited by PubMed: 24474783 DOI: 10.1073/PNAS.1311263111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation