4BSW

Heterodimeric Fc Antibody Azymetric Variant 2

4BSW の概要

• エントリーDOI: 10.2210/pdb4bsw/pdb
• 関連するPDBエントリー: 4BSV
• 分子名称: HETERODIMERIC FC ANTIBODY AZYMETRIC VARIANT 2, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (6 entities in total)
• 機能のキーワード: immune system, bispecific, scaffold, antibody engineering, fc domain, igg, igg1, immunoglobulin g, zymeworks inc.
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54716.58

構造登録者

Suits, M.D.L.,Spreter, T.,Cabrera, E.E.,Dixit, S.B.,Lario, P.I.,Poon, D.K.Y.,D'Angelo, I.E.P.,Boulanger, M.J. (登録日: 2013-06-11, 公開日: 2013-08-21, 最終更新日: 2023-12-20)

• 主引用文献: Von Kreudenstein, T.S.,Escobar-Carbrera, E.,Lario, P.I.,D'Angelo, I.,Brault, K.,Kelly, J.,Durocher, Y.,Baardsnes, J.,Woods, R.J.,Xie, M.H.,Girod, P.,Suits, M.D.L.,Boulanger, M.J.,Poon, D.K.Y.,Ng, G.Y.K.,Dixit, S.B.; Improving Biophysical Properties of a Bispecific Antibody Scaffold to Aid Developability: Quality by Molecular Design.; Mabs, 5:646-, 2013; PubMed: 23924797; DOI: 10.4161/MABS.25632

実験手法

X-RAY DIFFRACTION (2.15 Å)