4BS2
NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA
Summary for 4BS2
Entry DOI | 10.2210/pdb4bs2/pdb |
NMR Information | BMRB: 19290 |
Descriptor | TAR DNA-BINDING PROTEIN 43, 5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3' (2 entities in total) |
Functional Keywords | transcription, hnrnp, cystic fibrosis, neurodegeneration, isotope-labelled rna, hammerhead ribozyme |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Nucleus : Q13148 |
Total number of polymer chains | 2 |
Total formula weight | 23873.09 |
Authors | Lukavsky, P.J.,Daujotyte, D.,Tollervey, J.R.,Ule, J.,Stuani, C.,Buratti, E.,Baralle, F.E.,Damberger, F.F.,Allain, F.H.T. (deposition date: 2013-06-06, release date: 2013-11-13, Last modification date: 2024-06-19) |
Primary citation | Lukavsky, P.J.,Daujotyte, D.,Tollervey, J.R.,Ule, J.,Stuani, C.,Buratti, E.,Baralle, F.E.,Damberger, F.F.,Allain, F.H.T. Molecular Basis of Ug-Rich RNA Recognition by the Human Splicing Factor Tdp-43 Nat.Struct.Mol.Biol., 20:1443-, 2013 Cited by PubMed: 24240615DOI: 10.1038/NSMB.2698 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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