4BRX

Focal Adhesion Kinase catalytic domain in complex with a diarylamino- 1,3,5-triazine inhibitor

4BRX の概要

• エントリーDOI: 10.2210/pdb4brx/pdb
• 分子名称: FOCAL ADHESION KINASE 1, 2-(4-(2-methoxy-4-morpholinophenylamino)-1,3,5-triazin-2-ylamino)-N-methylbenzamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: transferase, kinase inhibitor, atp-binding, integrin signaling
• 由来する生物種: GALLUS GALLUS (CHICKEN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32263.35

構造登録者

Le Coq, J.,Lietha, D. (登録日: 2013-06-05, 公開日: 2013-07-24, 最終更新日: 2023-12-20)

• 主引用文献: Dao, P.,Jarray, R.,Le Coq, J.,Lietha, D.,Loukaci, A.,Lepelletier, Y.,Hadj-Slimane, R.,Garbay, C.,Raynaud, F.,Chen, H.; Synthesis of Novel Diarylamino-1,3,5-Triazine Derivatives as Fak Inhibitors with Anti-Angiogenic Activity.; Bioorg.Med.Chem.Lett., 23:4552-, 2013; PubMed: 23845217; DOI: 10.1016/J.BMCL.2013.06.038

実験手法

X-RAY DIFFRACTION (2.05 Å)