4BQ7

Crystal structure of the RGMB-Neo1 complex form 2

4BQ7 の概要

• エントリーDOI: 10.2210/pdb4bq7/pdb
• 関連するPDBエントリー: 4BQ6 4BQ8 4BQ9 4BQB 4BQC
• 分子名称: NEOGENIN, RGM DOMAIN FAMILY MEMBER B (3 entities in total)
• 機能のキーワード: cell adhesion
• 由来する生物種: MUS MUSCULUS (HOUSE MOUSE); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 140971.78

構造登録者

Bell, C.H.,Healey, E.,van Erp, S.,Bishop, B.,Tang, C.,Gilbert, R.J.C.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C. (登録日: 2013-05-30, 公開日: 2013-06-12, 最終更新日: 2024-10-16)

主引用文献

Bell, C.H.,Healey, E.,Van Erp, S.,Bishop, B.,Tang, C.,Gilbert, R.J.C.,Aricescu, A.R.,Pasterkamp, R.J.,Siebold, C.
Structure of the Repulsive Guidance Molecule (Rgm)-Neogenin Signaling Hub
Science, 341:77-, 2013

PubMed Abstract: Repulsive guidance molecule family members (RGMs) control fundamental and diverse cellular processes, including motility and adhesion, immune cell regulation, and systemic iron metabolism. However, it is not known how RGMs initiate signaling through their common cell-surface receptor, neogenin (NEO1). Here, we present crystal structures of the NEO1 RGM-binding region and its complex with human RGMB (also called dragon). The RGMB structure reveals a previously unknown protein fold and a functionally important autocatalytic cleavage mechanism and provides a framework to explain numerous disease-linked mutations in RGMs. In the complex, two RGMB ectodomains conformationally stabilize the juxtamembrane regions of two NEO1 receptors in a pH-dependent manner. We demonstrate that all RGM-NEO1 complexes share this architecture, which therefore represents the core of multiple signaling pathways.

PubMed: 23744777
DOI: 10.1126/SCIENCE.1232322

実験手法

X-RAY DIFFRACTION (6.601 Å)