4BKJ

Crystal structure of the human DDR1 kinase domain in complex with imatinib

Summary for 4BKJ

• Entry DOI: 10.2210/pdb4bkj/pdb
• Related: 4BKI
• Descriptor: EPITHELIAL DISCOIDIN DOMAIN-CONTAINING RECEPTOR 1, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase, receptor, rtk, collagen, discoidin domain, receptor tyrosine kinase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted . Isoform 4: Cell membrane; Single-pass type I membrane protein: Q08345
• Total number of polymer chains: 2
• Total formula weight: 73674.69

Authors

Canning, P.,Elkins, J.M.,Goubin, S.,Mahajan, P.,Krojer, T.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A. (deposition date: 2013-04-25, release date: 2013-05-22, Last modification date: 2023-12-20)

• Primary citation: Canning, P.,Elkins, J.M.,Goubin, S.,Mahajan, P.,Krojer, T.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.; Structural Mechanisms Determining Inhibition of the Collagen Receptor Ddr1 by Selective and Multi-Targeted Type II Kinase Inhibitors; J.Mol.Biol., 426:2457-, 2014; PubMed: 24768818; DOI: 10.1016/J.JMB.2014.04.014

Experimental method

X-RAY DIFFRACTION (1.7 Å)