4BE1

PFV intasome with inhibitor XZ-116

Summary for 4BE1

Entry DOI	10.2210/pdb4be1/pdb
Related	2X6N 2X6S 2X74 2X78 4BAC 4BDY 4BDZ 4BE0 4BE2
Descriptor	INTEGRASE, 19 NUCLEOTIDE PREPROCESSED PFV DONOR DNA (NON-TRANSFERRED STRAND), 17 NUCLEOTIDE PREPROCESSED PFV DONOR DNA (TRANSFERRED STRAND), ... (10 entities in total)
Functional Keywords	transferase-dna complex, protein-dna complex, dna integration, endonuclease, metal-binding, multifunctional enzyme, nuclease, nucleotidyltransferase, transferase, viral nucleoprotein, virion, dna-binding, zinc binding, hhcc motif, viral protein, recombination, inhibitor, recombination-inhibitor-dna complex, transferase/dna
Biological source	HUMAN SPUMARETROVIRUS More
Total number of polymer chains	4
Total formula weight	101064.21
Authors	Hare, S.,Cherepanov, P. (deposition date: 2012-10-08, release date: 2012-10-31, Last modification date: 2023-12-20)
Primary citation	Metifiot, M.,Maddali, K.,Johnson, B.C.,Hare, S.,Smith, S.J.,Zhao, X.Z.,Marchand, C.,Burke, T.R.,Hughes, S.H.,Cherepanov, P.,Pommier, Y. Activities, Crystal Structures and Molecular Dynamics of Dihydro-1H-Isoindole Derivatives, Inhibitors of HIV-1 Integrase. Acs Chem.Biol., 8:209-, 2013 Cited by PubMed: 23075516 DOI: 10.1021/CB300471N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.71 Å)

Structure validation