4BDT

Human acetylcholinesterase in complex with huprine W and fasciculin 2

4BDT の概要

• エントリーDOI: 10.2210/pdb4bdt/pdb
• 関連するPDBエントリー: 1B41 1F8U 1FSC 1FSS 1KU6 1MAH 1PUV 1PUW 1VZJ 2CLJ 2X8B 4BDS
• 分子名称: ACETYLCHOLINESTERASE, FASCICULIN-2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: hydrolase-inhibitor complex, butyrylcholinesterase, nerve transmission, inhibition, alpha-beta hydrolase, hydrolase/inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72746.45

構造登録者

Nachon, F.,Carletti, E.,Ronco, C.,Trovaslet, M.,Nicolet, Y.,Jean, L.,Renard, P.-Y. (登録日: 2012-10-06, 公開日: 2013-05-29, 最終更新日: 2023-12-20)

• 主引用文献: Nachon, F.,Carletti, E.,Ronco, C.,Trovaslet, M.,Nicolet, Y.,Jean, L.,Renard, P.Y.; Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.; Biochem. J., 453:393-399, 2013; PubMed: 23679855; DOI: 10.1042/BJ20130013

実験手法

X-RAY DIFFRACTION (3.104 Å)