2X8B
Crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-II
Summary for 2X8B
Entry DOI | 10.2210/pdb2x8b/pdb |
Related | 1B41 1F8U 1FSC 1FSS 1KU6 1MAH 1PUV 1PUW 1VZJ 2CLJ |
Descriptor | ACETHYLCHOLINESTERASE, FASCICULIN-2, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | hydrolase-toxin complex, cell junction, hydrolase, gpi-anchor, neurotransmitter degradation, tabun, aging, serine esterase, blood group antigen, hydrolase/toxin |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 72446.02 |
Authors | Carletti, E.,Colletier, J.P.,Nachon, F. (deposition date: 2010-03-08, release date: 2010-04-28, Last modification date: 2023-12-20) |
Primary citation | Carletti, E.,Colletier, J.P.,Dupeux, F.,Trovaslet, M.,Masson, P.,Nachon, F. Structural evidence that human acetylcholinesterase inhibited by tabun ages through O-dealkylation. J. Med. Chem., 53:4002-4008, 2010 Cited by PubMed: 20408548DOI: 10.1021/jm901853b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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