1VZJ

Structure of the tetramerization domain of acetylcholinesterase: four-fold interaction of a WWW motif with a left-handed polyproline helix

Summary for 1VZJ

• Entry DOI: 10.2210/pdb1vzj/pdb
• Related: 1B41 1F8U 2CLJ
• Descriptor: ACETYLCHOLINESTERASE, ACETYLCHOLINESTERASE COLLAGENIC TAIL PEPTIDE (3 entities in total)
• Functional Keywords: hydrolase, acetylcholinesterase, synapse, neurotransmitter degradation, alternative splicing, disease mutation.
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 10
• Total formula weight: 44397.43

Authors

Dvir, H.,Harel, M.,Bon, S.,Liu, W.-Q.,Vidal, M.,Garbay, C.,Sussman, J.L.,Massoulie, J.,Silman, I. (deposition date: 2004-05-20, release date: 2005-01-10, Last modification date: 2019-10-16)

• Primary citation: Dvir, H.,Harel, M.,Bon, S.,Liu, W.-Q.,Vidal, M.,Garbay, C.,Sussman, J.L.,Massoulie, J.,Silman, I.; The Synaptic Acetylcholinesterase Tetramer Assembles Around a Polyproline-II Helix; Embo J., 23:4394-, 2004; PubMed: 15526038; DOI: 10.1038/SJ.EMBOJ.7600425

Experimental method

X-RAY DIFFRACTION (2.35 Å)