4BDS

Human butyrylcholinesterase in complex with tacrine

Summary for 4BDS

Entry DOI	10.2210/pdb4bds/pdb
Related	1EHO 1EHQ 1KCJ 1P0I 1P0M 1P0P 1P0Q 1XLU 1XLV 1XLW 2J4C 2WID 2WIF 2WIG 2WIJ 2WIK 2WIL 2WSL 2XMB 2XMC 2XMD 2XMG 2XQF 2XQG 2XQI 2XQJ 2XQK 2Y1K 4AQD 4AXB 4B0O 4B0P 4BBZ
Descriptor	CHOLINESTERASE, UNKNOWN ATOM OR ION, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
Functional Keywords	hydrolase, nerve transmission, inhibitior, alpha-beta hydrolase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	62600.12
Authors	Nachon, F.,Carletti, E.,Ronco, C.,Trovaslet, M.,Nicolet, Y.,Jean, L.,Renard, P.-Y. (deposition date: 2012-10-06, release date: 2013-05-29, Last modification date: 2023-12-20)
Primary citation	Nachon, F.,Carletti, E.,Ronco, C.,Trovaslet, M.,Nicolet, Y.,Jean, L.,Renard, P. Crystal Structures of Human Cholinesterases in Complex with Huprine W and Tacrine: Elements of Specificity for Anti-Alzheimer'S Drugs Targeting Acetyl- and Butyrylcholinesterase. Biochem.J., 453:393-, 2013 Cited by PubMed: 23679855 DOI: 10.1042/BJ20130013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation