4BCO

Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor

4BCO の概要

• エントリーDOI: 10.2210/pdb4bco/pdb
• 関連するPDBエントリー: 4ACM 4BCF 4BCG 4BCH 4BCI 4BCJ 4BCK 4BCL 4BCM 4BCN 4BCP 4BCQ 4BCR
• 分子名称: CYCLIN-DEPENDENT KINASE 2, CYCLIN-A2, 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile, ... (6 entities in total)
• 機能のキーワード: transferase-cell cycle complex, cdk-cyclin complex, cyclin-inhibitor, structure-based drug design, transferase/cell cycle
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton, centrosome: P24941; Nucleus: P30274
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130086.60

構造登録者

Hole, A.J.,Baumli, S.,Wang, S.,Endicott, J.A.,Noble, M.E.M. (登録日: 2012-10-02, 公開日: 2013-01-09, 最終更新日: 2013-02-27)

• 主引用文献: Hole, A.J.,Baumli, S.,Shao, H.,Shi, S.,Pepper, C.,Fischer, P.M.,Wang, S.,Endicott, J.A.,Noble, M.E.M.; Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.; J.Med.Chem., 56:660-, 2013; PubMed: 23252711; DOI: 10.1021/JM301495V

実験手法

X-RAY DIFFRACTION (2.05 Å)