4BCO
Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | CYCLIN-DEPENDENT KINASE 2 | polymer | 300 | 34200.6 | 2 | UniProt (P24941) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CELL DIVISION PROTEIN KINASE 2, P33 PROTEIN KINASE |
| 2 | B, D (B, D) | CYCLIN-A2 | polymer | 262 | 30067.7 | 2 | UniProt (P30274) Pfam (PF00134) Pfam (PF02984) | BOS TAURUS (BOVINE) | CYCLIN-A |
| 3 | E, I (A, C) | 2-[[3-(4-ethanoyl-1,4-diazepan-1-yl)phenyl]amino]-4-[4-methyl-2-(methylamino)-1,3-thiazol-5-yl]pyrimidine-5-carbonitrile | non-polymer | 462.6 | 2 | Chemie (T6Q) | |||
| 4 | F, G, J, K (B, D) | MONOTHIOGLYCEROL | non-polymer | 108.2 | 4 | Chemie (SGM) | |||
| 5 | H, L (B, D) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 6 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 519 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 128536.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1549.9 | |
| All* | Total formula weight | 130086.6 |
