4BC6

Crystal structure of human serine threonine kinase-10 bound to novel Bosutinib Isoform 1, previously thought to be Bosutinib

Replaces:  3ZZ2

Summary for 4BC6

• Entry DOI: 10.2210/pdb4bc6/pdb
• Related: 2J7T 4AOT
• Descriptor: SERINE/THREONINE-PROTEIN KINASE 10, 4-[(3,5-DICHLORO-4-METHOXYPHENYL)AMINO]-6-METHOXY-7-[3-(4-METHYLPIPERAZIN-1-YL)PROPOXY]QUINOLINE-3-CARBONITRILE, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane ; Peripheral membrane protein : O94804
• Total number of polymer chains: 1
• Total formula weight: 33720.80

Authors

Vollmar, M.,Szklarz, M.,Chaikuad, A.,Elkins, J.,Savitsky, P.,Azeez, K.A.,Salah, E.,Krojer, T.,Canning, P.,Muniz, J.R.C.,Bountra, C.,Arrowsmith, C.H.,von Delft, F.,Weigelt, J.,Edwards, A.,Knapp, S. (deposition date: 2012-10-01, release date: 2012-10-10, Last modification date: 2023-12-20)

• Primary citation: Vollmar, M.,Szklarz, M.,Chaikuad, A.,Elkins, J.,Savitsky, P.,Azeez, K.A.,Salah, E.,Krojer, T.,Canning, P.,Muniz, J.R.C.,Bountra, C.,Arrowsmith, C.H.,Weigelt, J.,Edwards, A.,von Delft, F.,Knapp, S.; Crystal Structure of Human Serine Threonine Kinase- 10 Bound to Novel Bosutinib Isoform 1, Previously Thought to be Bosutinib; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)