4BBG

Crystal structure of human kinesin Eg5 in complex with 3-(((2-Aminoethyl)sulfanyl)(3-ethylphenyl) phenylmethyl)phenol

Summary for 4BBG

Related1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 4A1Z 4A28 4A50 4A51 4A5Y 4AP0 4AQV 4AQW 4AS7 4B7B
DescriptorKINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordscell cycle, mitosis, inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P52732
Total number of polymer chains1
Total molecular weight42047.87
Authors
Kaan, H.Y.K.,Kozielski, F. (deposition date: 2012-09-22, release date: 2013-05-15)
Primary citation
Good, J.A.D.,Wang, F.,Rath, O.,Kaan, H.Y.K.,Talapatra, S.K.,Podgorski, D.,Mackay, S.P.,Kozielski, F.
Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
J.Med.Chem., 56:1878-, 2013
PubMed: 23394180 (PDB entries with the same primary citation)
DOI: 10.1021/JM3014597
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21881.2%6.5%6.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution