4BBF

Aminoalkylpyrimidine Inhibitor Complexes with JAK2

Summary for 4BBF

• Entry DOI: 10.2210/pdb4bbf/pdb
• Related: 2B7A 2W1I 2XA4 4AQC 4BBE
• Descriptor: TYROSINE-PROTEIN KINASE JAK2, (2R)-N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide (3 entities in total)
• Functional Keywords: transferase, inhibitor
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Endomembrane system ; Peripheral membrane protein : O60674
• Total number of polymer chains: 4
• Total formula weight: 141758.20

Authors

Li, J. (deposition date: 2012-09-21, release date: 2012-11-21, Last modification date: 2017-06-28)

• Primary citation: Forsyth, T.,Kearney, P.C.,Kim, B.G.,Johnson, H.W.B.,Aay, N.,Arcalas, A.,Brown, D.S.,Chan, V.,Chen, J.,Du, H.,Epshteyn, S.,Galan, A.A.,Huynh, T.P.,Ibrahim, M.A.,Kane, B.,Koltun, E.,Mann, G.,Meyr, L.E.,Lee, M.S.,Lewis, G.L.,Noguchi, R.T.,Pack, M.,Ridgway, B.H.,Shi, X.,Takeuchi, C.S.,Zu, P.,Leahy, J.W.,Nuss, J.M.,Aoyama, R.,Engst, S.,Gendreau, S.B.,Kassees, R.,Li, J.,Lin, S.-H.,Martini, J.-F.,Stout, T.,Tong, P.,Woolfrey, J.,Zhang, W.,Yu, P.; Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors; Bioorg.Med.Chem.Lett., 22:7653-, 2012; PubMed: 23127890; DOI: 10.1016/J.BMCL.2012.10.007

Experimental method

X-RAY DIFFRACTION (2 Å)