4BBF
Aminoalkylpyrimidine Inhibitor Complexes with JAK2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | TYROSINE-PROTEIN KINASE JAK2 | polymer | 298 | 34995.0 | 4 | UniProt (O60674) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | JANUS KINASE 2, JAK-2 |
| 2 | E, F, G, H (A, B, C, D) | (2R)-N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]pyrrolidine-2-carboxamide | non-polymer | 444.5 | 4 | Chemie (O19) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 435 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 839 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 837 | - | expression tag |
| Ser 838 | - | expression tag |
| Asn 976 | Asp 976 | engineered mutation |
| Glu 1133 | - | expression tag |
| Phe 1134 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 139980.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1778.1 | |
| All* | Total formula weight | 141758.2 |
