4B9D
Crystal Structure of Human NIMA-related Kinase 1 (NEK1) with inhibitor.
Summary for 4B9D
Entry DOI | 10.2210/pdb4b9d/pdb |
Related | 4APC |
Descriptor | SERINE/THREONINE-PROTEIN KINASE NEK1, [4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | transferase, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 80649.26 |
Authors | Elkins, J.M.,Hanchuk, T.D.M.,Lovato, D.V.,Basei, F.L.,Meirelles, G.V.,Kobarg, J.,Szklarz, M.,Vollmar, M.,Mahajan, P.,Rellos, P.,Zhang, Y.,Krojer, T.,Pike, A.C.W.,Canning, P.,von Delft, F.,Raynor, J.,Bountra, C.,Arrowsmith, C.,Edwards, A.,Knapp, S. (deposition date: 2012-09-04, release date: 2012-09-19, Last modification date: 2023-12-20) |
Primary citation | Melo-Hanchuk, T.D.,Slepicka, P.F.,Meirelles, G.V.,Basei, F.L.,Lovato, D.V.,Granato, D.C.,Pauletti, B.A.,Domingues, R.R.,Leme, A.F.P.,Pelegrini, A.L.,Lenz, G.,Knapp, S.,Elkins, J.M.,Kobarg, J. NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin. Sci Rep, 7:5445-5445, 2017 Cited by PubMed: 28710492DOI: 10.1038/s41598-017-05325-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report