4B6S

Structure of Helicobacter pylori Type II Dehydroquinase inhibited by (2S)-2-Perfluorobenzyl-3-dehydroquinic acid

Summary for 4B6S

• Entry DOI: 10.2210/pdb4b6s/pdb
• Related: 1J2Y 2C4V 2C4W 2C57 2WKS 2XB9 2XD9 2XDA 4B6R
• Descriptor: 3-DEHYDROQUINATE DEHYDRATASE, (1R,2S,4S,5R)-2-(2,3,4,5,6-pentafluorophenyl)methyl-1,4,5-trihydroxy-3-oxocyclohexane-1-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: lyase
• Biological source: HELICOBACTER PYLORI 26695
• Total number of polymer chains: 3
• Total formula weight: 56703.39

Authors

Otero, J.M.,Llamas-Saiz, A.L.,Lence, E.,Tizon, L.,Peon, A.,Prazeres, V.F.V.,Lamb, H.,Hawkins, A.R.,Gonzalez-Bello, C.,van Raaij, M.J. (deposition date: 2012-08-14, release date: 2012-12-19, Last modification date: 2023-12-20)

• Primary citation: Lence, E.,Tizon, L.,Otero, J.M.,Peon, A.,Prazeres, V.F.,Llamas-Saiz, A.L.,Fox, G.C.,van Raaij, M.J.,Lamb, H.,Hawkins, A.R.,Gonzalez-Bello, C.; Mechanistic basis of the inhibition of type II dehydroquinase by (2S)- and (2R)-2-benzyl-3-dehydroquinic acids.; ACS Chem. Biol., 8:568-577, 2013; PubMed: 23198883; DOI: 10.1021/cb300493s

Experimental method

X-RAY DIFFRACTION (1.9 Å)