4B55

Crystal Structure of the Covalent Adduct Formed between Mycobacterium marinum Aryalamine N-acetyltransferase and Phenyl vinyl ketone a derivative of Piperidinols

Summary for 4B55

Entry DOI	10.2210/pdb4b55/pdb
Descriptor	ARYLAMINE N-ACETYLTRANSFERASE NAT, 3-hydroxy-1-phenylpropan-1-one (3 entities in total)
Functional Keywords	transferase, tuberculosis, covalent inhibitor
Biological source	MYCOBACTERIUM MARINUM
Total number of polymer chains	1
Total formula weight	31101.20
Authors	Abuhammad, A.,Fullam, E.,Lowe, E.D.,Staunton, D.,Kawamura, A.,Westwood, I.M.,Bhakta, S.,Garner, A.C.,Wilson, D.L.,Seden, P.T.,Davies, S.G.,Russell, A.J.,Garman, E.F.,Sim, E. (deposition date: 2012-08-02, release date: 2013-01-16, Last modification date: 2023-12-20)
Primary citation	Abuhammad, A.,Fullam, E.,Lowe, E.D.,Staunton, D.,Kawamura, A.,Westwood, I.M.,Bhakta, S.,Garner, A.C.,Wilson, D.L.,Seden, P.T.,Davies, S.G.,Russell, A.J.,Garman, E.F.,Sim, E. Piperidinols that Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages. Plos One, 7:52790-, 2012 Cited by PubMed: 23285185 DOI: 10.1371/JOURNAL.PONE.0052790 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation