4AWN

Structure of recombinant human DNase I (rhDNaseI) in complex with Magnesium and Phosphate.

Summary for 4AWN

• Entry DOI: 10.2210/pdb4awn/pdb
• Descriptor: DEOXYRIBONUCLEASE-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: hydrolase, endonuclease, pulmozyme
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 30332.16

Authors

Parsiegla, G.,Noguere, C.,Santell, L.,Lazarus, R.A.,Bourne, Y. (deposition date: 2012-06-04, release date: 2013-01-09, Last modification date: 2023-12-20)

• Primary citation: Parsiegla, G.,Noguere, C.,Santell, L.,Lazarus, R.A.,Bourne, Y.; The Structure of Human DNase I Bound to Magnesium and Phosphate Ions Points to a Catalytic Mechanism Common to Members of the DNase I-Like Superfamily.; Biochemistry, 51:10250-, 2012; PubMed: 23215638; DOI: 10.1021/BI300873F

Experimental method

X-RAY DIFFRACTION (1.95 Å)